[Effectiveness of synthetic opioid peptide dalargin in acute myocardial infarction]. / Effektivnost' sinteticheskogo opioidnogo peptida dalargina pri ostrom infarkte miokarda.

The synthetic opioid peptide dalargin was examined for its potency in 86 patients with primary transmural myocardial infarction. The agent was shown to contribute to a decrease in initially elevated plasma cortisol levels and an increase in beta-endorphine and leucine-enkephaline concentrations. Myocardial contractility became normal by reducing the hyperfunction of its intact segments. This was evidenced by antistressor effects of the drug. However, no substantial effect was found on the clinical course of the disease, evolution of myocardial infarction, plasma CPK MB. The left ventricular contractility showed severe depression.

[Emoxipin in reperfusion of ischemic myocardium in dogs: effects on infarct size and plasma creatine kinase activity]. / Emoksipin pri reperfuzii ishemicheskogo miokarda u sobak: vliianie na razmer infarkta i kreatinkinaznuiu aktivnost' plazmy krovi.

The effects of synthetic antioxidant emoxypine on infarct size and plasma creatine kinase (CK) activity was studied on open-chest anesthetized dogs with 180-min myocardial ischemia followed by reperfusion. Emoxypine (10 and 40 mg/kg) was injected intravenously, beginning since 120th min of coronary artery occlusion. Emoxypine (10 mg/kg) resulted in infarct size limitation and reduction in plasma CK activity. An increase in dose of emoxypine to 40 mg/kg largely attenuated its protective effect on infarct size. CK activity during post-ischemic reperfusion was even higher in emoxypine (40 mg/kg) group compared with control. Augmented CK leakage from irreversibly injured myocardium to plasma under these experimental conditions may be owing to preservation of microvascular integrity and improving of drainage of infarcted tissue exerted by emoxypine.

[Effect of dibunol and isoptin on the creatine kinase and myoglobin content of the blood serum in dogs undergoing postischemic coronary reperfusion]. / Vliianie dibunola i izoptina na soderzhanie kreatinkinazy i mioglobina v syvorotke krovi sobak pri postishemicheskoi koronarnoi reperfuzii.

The effect of an antioxidant dibunol and calcium antagonist verapamil on postperfusion release of myoglobin (Mb) and MB-creatine kinase (MB-CK) has been assessed in 30 dogs with experimental coronary occlusive myocardial infarction. It has been shown that reperfusion after 3-hour ischemia does not only accelerate the release of intracellular proteins, but also leads to pronounced myoglobinemia and blood enzymes. In postischemic blood flow recovery with combined dibunol and verapamil preliminary injections, an almost threefold decrease in MB-CK and Mb blood content, as compared to "reperfusion" indexes, was observed by the 10th minute of reperfusion.

[Therapeutic possibilities of using phosphocreatine in complicated myocardial infarct]. / Terapevticheskie vozmozhnosti primeneniia fosfokreatina pri oslozhnennom infarkte miokarda.

A total of 40 patients with complicated myocardial infarction (MI), with life threatening arrhythmias and congestive heart failure. II-IV degree after Walk's classification, with a concomitant pathology were investigated. Phosphocreatine (PC) therapy (i. v. infusions for 3 days at a total dose of 144 g) made a positive effect on a course of disease. A degree of clinical symptoms of heart failure lessened in 26 patients, disturbed cardiac rhythm got stable in 23 patients. A PC positively inotropic effect was observed. The comparison of the results of PC therapy with those of 173 MI patients on routine therapy showed heart contractility preserved at a higher level and the improvement of gas exchange. A conclusion was made of a favorable effect of the drug on a course of complicated MI.

[Rate of development and the size of the necrotic focus in patients with myocardial infarct treated by intracoronary thrombolysis]. / Skorost' formirovaniia i velichina ochaga nekroza u bol'nykh infarktom miokarda pri provedenii vnutrikoronarnogo trombolizisa.

Streptokinase intracoronary thrombolytic therapy (ITT) was given to 68 of 135 patients with large-focal myocardial infarction (MI) admitted to hospital within 6 hours of the attack. Coronary flow was recovered in 31 MI patients. The size of the necrotic focus was assessed on the basis of precordial cartograms from 35 ECG leads and serial measurements of MB CPK activity. ITT achieving successful thrombolysis is conducive to rapid formation and accelerated repair of the necrotic focus in MI patients. The recovery of coronary circulation after 3 hours of infarction was accompanied by the reperfusion syndrome, i. e. rapid necrotization of the ischemized region, a considerable release of MB CPK into the circulation, complex cardiac rhythm and conductivity disorders, and signs of transient heart failure.

[Effect of systemic thrombolytic therapy on necrotic focus formation in myocardial infarct patients]. / Vliianie sistemnoi tromboliticheskoi terapii na formirovanie ochaga nekroza u bol'nykh infarktom miokarda.

The formation of the myocardial necrotic focus was assessed by precardial charting at 35 leads and the serial determination of CPK activity and MB fraction in 50 patients receiving the systemic thrombolytic therapy and 52 patients of the control group. Thrombolytic therapy initiated within the first 6 h of the disease was shown to facilitate the limitation of the extent of myocardial infarction through a more rapid stabilization of the necrotic focus. The calculated extent of myocardial infarction in patients treated with thrombolytic drugs was 37.4% less than in the control group. A beneficial clinical effect of thrombolytic therapy was demonstrated.

[Sensitivity of creatine phosphokinase in early diagnosis of myocardial infarction and improvement of the test's specificity by determination of the rate of increase of enzyme activity]. / Chuvstvitel'nost' kreatinfosfokinazy v rannei diagnostike infarkta miokarda i povyshenie spetsifichnosti testa putem opredeleniia skorosti prirosta aktivnosti fermenta.

The activity of serum enzymes: creatine phosphokinase (CPK), CPK isoenzyme MB and asparagine aminotransferase--was examined every 1-3 hours after the onset of a painful attack in 68 patients with "determined" (according to the 1979 WHO classification) myocardial infarction (DMI) and 32 patients with unstable angina pectoris. The activity of all three enzymes was increased in 100% of DMI cases. The rate of enzyme activity increment (delta E/delta T) calculated for the first 3-12 hours of the disease demonstrated that absolute delta E/delta T values for CPK were significantly higher than those for other enzymes. The CPK delta E/delta T was several times as high in DMI patients as it was in patients with unstable angina. Measurement of the rate of CPK activity increment over any 6-hour interval within the first day after the painful attack is suggested as a way of further improvement of the test specificity.

[Information value of different blood serum chemiluminescence indices in acute myocardial infarct]. / Informativnaia tsennost' razlichnykh pokazatelei khemiliuminestsentsii syvorotki krovi bol'nykh ostrym infarktom miokarda.

The study of informativeness of varying parameters of induced chemifluorescence reflecting the intensity of free-radical oxygenation of lipids and their dependence on the degree of necrotic damage of the myocardium, determined by the activity of creatine phosphokinase and its cardiospecific isoenzyme MB. 19 patients and 20 healthy individuals were examined. The results show that inhibition of induced chemifluorescence of the blood serum in the period of developing necrotic changes is directly dependent on the content of products of the ischaemic destruction of the myocardium.